Surgery or radiotherapy is the gold standard treatment for low- to intermediate-risk localized prostate cancer patients. Still, the side effects of the treatment and possible patient comorbidities might hamper patients from allowing these kinds of approaches.

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A myriad of molecular-based risk assessment tests derived from serum, urine, and tissue have emerged to improve the specificity for detection and stratification of clinically significant prostate cancer.
Multiparametric magnetic resonance imaging (mpMRI) can be used in conjunction with the standard transrectal ultrasound (TRUS)-guided biopsy to improve detection of clinically significant
Prostate multiparametric magnetic resonance imaging (mpMRI) has emerged as the imaging method best able to detect clinically significant prostate cancer and to guide biopsy.
Some men with early stage (localized) 